stratum radiatum · extracellular / voltage-clamp teaching model
Readout
Both windows track the same underlying change in synaptic strength; this switches units and the sample trace shape only.
Induction protocol
−20 mV
−70 mV (rest)0 mV
Normally EPSP summation depolarizes CA1 pyramidal cells during a tetanus. Here you set it directly, decoupled from the presynaptic pattern above, so you can probe NMDAR coincidence detection on its own.
Run
NMDAR coincidence detection
Mg²⁺ block relieved—
NMDAR Ca²⁺ influx (last induction)—
Time course — % baseline response
t = simulated recording time (min)fEPSP slope, mV/ms
Sample trace
baselinecurrentstimulus
inward current
t (min)
% baseline
fEPSP slope (mV/ms)
Session status
Protocol run
none yet
APV present
no
Holding potential
−20 mV
Current response
100 %
Run a baseline, choose a protocol, then induce LTP.